August 31, 2023
Article

Unlocking the Secrets of Longevity: How Cognitive Reserve and Physical Activity Shape Well-Being in the Blue Zones

The world is aging rapidly, making it crucial to understand how to age well. The Blue Zones—areas like Sardinia, Okinawa, and Ikaria—are home to some of the world's longest-lived people. One key to their longevity is the concept of Health-Related Quality of Life (HRQoL), which includes physical well-being, mental health, and social engagement. Regular physical activity, even simple walking, has been shown to protect against chronic diseases and cognitive decline, enhancing HRQoL.

Another cornerstone of aging well is mental well-being. In these longevity hotspots, older individuals report higher life satisfaction and fewer depressive symptoms compared to others. This is where the concept of "Cognitive Reserve" comes into play. Cognitive Reserve is essentially the brain's ability to adapt and compensate for age-related changes, helping to maintain mental and functional health.

The study delves into how Cognitive Reserve acts as a mediator between physical health and mental well-being. It also explores gender differences in these factors. The findings suggest that both physical and mental activities contribute to successful aging, offering valuable insights for anyone interested in extending their healthspan.

Article Information

Abstract

The main purpose of this study was to examine the mediating role of cognitive reserve in the relationship between functional health (expressed through the amount and intensity of performed physical activity objectively assessed using wearable accelerometers) and psychological well-being (i.e., assessed in terms of self-reported depressive signs) of older people living in an area of exceptional longevity, the so-called Sardinian Blue Zone. A further goal was to investigate the impact of gender on the cognitive reserve and physical health of our participants, using global cognitive functioning as a covariate. A battery of tests assessing motor efficiency, cognitive reserve, global cognitive functioning, and self-reported depressive symptoms was individually presented to 120 community dwellers (Mage = 82 years, SD = 8.4 years) of the Sardinian Blue Zone. Significant associations were found between cognitive reserve, motor efficiency, and self-reported depressive signs. Moreover, three mediation analyses documented that distinct indexes of cognitive reserve and motor efficiency explain 27.2-31% of the variance in the self-reported depression condition. Following this, it was also found that people with scarce cognitive reserve tended to exhibit significant signs of depression and showed worse motor abilities. In addition, after controlling for the effect of global cognitive functioning, motor efficiency, and cognitive reserve were generally more preserved in males than in females. Overall, these findings suggest that cognitive reserve is a compensatory resource that contributes significantly to the enhancement of health-related quality of life in the last decades of life.