Abstract

Objectives: Our study evaluated the prospective association between the consumption of caffeine-containing beverages at midlife and the risk of physical frailty at late life within a population-based cohort of Chinese adults living in Singapore over a follow-up period of 20 years.

Design: Prospective cohort study.

Setting and participants: We used data from 12,583 participants from the baseline and third follow-up interviews of the XXXXXXXXXXXXXXXX. Participants had a mean age of 53 years at baseline (1993-1998), and mean age of 73 years during the third follow-up (2014-2017).

Methods: At baseline, habitual consumption of caffeine-containing beverages was evaluated using a validated semi-quantitative food-frequency questionnaire. During the third follow-up, physical frailty was assessed using the modified Cardiovascular Health Study phenotype.

Results: Compared with non-daily drinkers, those who drank 4 or more cups of coffee daily had reduced odds of physical frailty (odds ratio [OR], 0.54; 95% CI, 0.38-0.76). Similarly, compared with those who hardly drank tea, participants who drank tea everyday also had reduced odds (OR, 0.82; 95% CI, 0.71-0.95). Total daily caffeine intake at midlife was associated with reduced likelihood of frailty at late life in a dose-response relationship (P_trend < .001). Relative to their counterparts in the lowest quartile of daily caffeine intake (0-67.6 mg/d), participants in the highest quartile (223.0-910.4 mg/d) had an OR of 0.77 (95% CI, 0.66-0.91). Higher caffeine consumption was associated with lower likelihood of being in the slowest quintile for timed up-and-go (TUG) and weakest quintile for handgrip strength.

Conclusions and implications: In this cohort of Chinese adults, higher consumption of caffeine at midlife, via coffee and tea, was associated with a reduced likelihood of physical frailty in late life.