
A recent study delves into how eating vegetables and fruits during midlife affects the risk of becoming physically frail later in life. It highlights that a consistent intake of vegetables has a notable protective effect against frailty, particularly evident through measures like handgrip strength—a key indicator of physical capability. Notably, the consumption of fruits, in this case, did not demonstrate a significant impact on frailty outcomes.
The research explored whether specific nutrients might explain the beneficial effects of vegetables. Intriguingly, when accounting for nutrients such as β-carotene, lutein, and folate, the protective link between vegetable intake and frailty became less pronounced. This suggests that these nutrients play a crucial role in mitigating frailty risks.
By underscoring the importance of vegetable consumption during midlife, the study supports the idea of dietary intervention as a feasible strategy for maintaining physical health into old age. It calls for further exploration into how specific nutrients contribute to such protective effects, potentially guiding future dietary recommendations.
Article Information
Intake of vegetables and fruits at midlife and the risk of physical frailty in later life
Published in J Nutr Health Aging. Yiqiang Chua K. et al.
Objectives: Our study evaluated the independent and overall associations of vegetable and fruit consumption at midlife with the likelihood of physical frailty in later life. We also investigated whether specific nutrients in these foods could have accounted for these associations, if present.
Design: Prospective cohort study.
Setting: A population-based cohort of Chinese adults followed over a period of 20 years in Singapore.
Participants: We used data from 11,959 subjects who participated in the baseline (1993-1998) and follow-up 3 (2014-2017) interviews of the Singapore Chinese Health Study.
Measurements: At baseline, dietary intake was evaluated using a validated food frequency questionnaire. During the follow-up 3 visits, physical frailty was assessed using a modified Cardiovascular Health Study phenotype that included weakness, slowness, exhaustion and weight loss. Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations with physical frailty.
Results: Participants had mean ages of 52 years at baseline, and 72 years at follow-up 3. Baseline intake of vegetables, but not of fruits, showed a dose-dependent inverse relationship with physical frailty at follow-up 3 (Ptrend = 0.001). Compared to participants in the lowest quintile of vegetable intake, those in the highest quintile had reduced odds of frailty [OR (95% CI): 0.73 (0.60-0.89)]. Among the components of physical frailty, vegetable intake had the strongest inverse association with weakness defined by handgrip strength [OR (95% CI) between extreme quintiles: 0.62 (0.52-0.73); Ptrend < 0.001]. In models that were individually adjusted for nutrients, the vegetable-frailty association was attenuated and no longer statistically significant after adjusting for the intake of β-carotene, lutein, folate, α-carotene, and isothiocyanates.
Conclusion: Increased midlife intake of vegetables was associated with reduced odds of physical frailty in later life, and the intake of β-carotene, lutein, folate, α-carotene, and isothiocyanates could have accounted for this association.